Wound Healing, Antimicrobial and Anti Fungal Activities of Ethanolic Leaf Extract of Aegle Marmelos in Rats

Aegle marmelos is a medicinal plant commonly known as bale. This plant contains different components of therapeutic value. The ethanolic extract of Aegle marmelos showed the presence of phytoconstituents like flavonoids, triterpenoids, coumarins, sterols, triterpenoids, alkaloids with other constituents. In present investigation, antibacterial, antifungal and wound healing effects of ethanolic extract of leaves of Aegle marmelos has been studied. This extract was formulated 4% Aegle marmelos ethanolic leaf extract ointment and was studied for its wound healing property against an excision wound on the skin of Wistar albino rats. The activity was compared with 2% framycetin ointment. Study shows faster wound healing with 4% Aegle marmelos ethanolic leaf extract ointment. On 12 th day biochemical parameters like hydroxyproline, collagen and hexosamine were determined from excised tissue and they were significantly increased in extract treated groups. Healed skin was also subjected to histopathological studies to examine the microscopic changes and it also supported the wound healing on application of extract ointment in treated group. Histopathological observations showed increase in granulation and rapid collagen turnover. It was concluded that wound healing actibity of ethanolic leaf extract of a Aegle marmelos was better and faster than framycetin ointment.